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1

Common conformational changes in flavodoxins induced by FMN and anion binding: The structure of Helicobacter pylori apoflavodoxin

Marta Martínez-Júlvez, Nunilo Cremades, Marta Bueno, Inmaculada Pérez-Dorado, Celia Maya, Santiago Cuesta-López, Diego Prada, Fernando Falo, Juan A. Hermoso, Javier Sancho

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2007

Language:

english

File:

PDF, 579 KB

english, 2007

2

Towards a new therapeutic target: Helicobacter pylori flavodoxin

Nunilo Cremades, Marta Bueno, Miguel Toja, Javier Sancho

Journal:

Biophysical Chemistry

Year:

2005

Language:

english

File:

PDF, 438 KB

english, 2005

3

Population of Nonnative States of Lysozyme Variants Drives Amyloid Fibril Formation

Buell, Alexander K., Dhulesia, Anne, Mossuto, Maria F., Cremades, Nunilo, Kumita, Janet R., Dumoulin, Mireille, Welland, Mark E., Knowles, Tuomas P. J., Salvatella, Xavier, Dobson, Christopher M.

Journal:

Journal of the American Chemical Society

Year:

2011

Language:

english

File:

PDF, 965 KB

english, 2011

4

The native-state ensemble of proteins provides clues for folding, misfolding and function

Nunilo Cremades, Javier Sancho, Ernesto Freire

Journal:

Trends in Biochemical Sciences

Year:

2006

Language:

english

File:

PDF, 195 KB

english, 2006

5

Direct Observation of the Interconversion of Normal and Toxic Forms of α-Synuclein

Nunilo Cremades, Samuel I.A. Cohen, Emma Deas, Andrey Y. Abramov, Allen Y. Chen, Angel Orte, Massimo Sandal, Richard W. Clarke, Paul Dunne, Francesco A. Aprile, Carlos W. Bertoncini, Nicholas W. Wood,

Journal:

Year:

2012

Language:

english

File:

PDF, 1.42 MB

english, 2012

6

Filling Small, Empty Protein Cavities: Structural and Energetic Consequences

Marta Bueno, Nunilo Cremades, José Luis Neira, Javier Sancho

Journal:

Journal of Molecular Biology

Year:

2006

Language:

english

File:

PDF, 479 KB

english, 2006

7

Structure and Properties of a Complex of α-Synuclein and a Single-Domain Camelid Antibody

Erwin J. De Genst, Tim Guilliams, Joke Wellens, Elizabeth M. O'Day, Christopher A. Waudby, Sarah Meehan, Mireille Dumoulin, Shang-Te Danny Hsu, Nunilo Cremades, Koen H.G. Verschueren, Els Pardon, Lode

Journal:

Journal of Molecular Biology

Year:

2010

Language:

english

File:

PDF, 1.79 MB

english, 2010

8

Nanobodies Raised against Monomeric α-Synuclein Distinguish between Fibrils at Different Maturation Stages

Guilliams, Tim, El-Turk, Farah, Buell, Alexander K., O'Day, Elizabeth M., Aprile, Francesco A., Esbjörner, Elin K., Vendruscolo, Michele, Cremades, Nunilo, Pardon, Els, Wyns, Lode, Welland, Mark E., S

Journal:

Journal of Molecular Biology

Year:

2013

Language:

english

File:

PDF, 945 KB

english, 2013

9

Investigating the Factors Affecting the Aggregation of Alpha-Synuclein using Single Molecule Fluorescence and Fast Flow Microfluidics

Horrocks, Mathew H., Cremades, Nunilo, Tosatto, Laura, Guilliams, Tim, De Genst, Erwin, Shim, Jung-uk, Dobson, Christopher M., Klenerman, David

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 61 KB

english, 2012

10

Single Molecule FRET Characterization of Oligomers from Alpha-Synuclein Early Onset Parkinson's Disease Mutants

Tosatto, Laura, Horrocks, Mathew H., Nunilo, Cremades, Guilliams, Tim, Serra, Mauro Dalla, Klenerman, David

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 47 KB

english, 2014

11

On the Mechanism of Nonspecific Inhibitors of Protein Aggregation: Dissecting the Interactions of α-Synuclein with Congo Red and Lacmoid

Lendel, Christofer, Bertoncini, Carlos W., Cremades, Nunilo, Waudby, Christopher A., Vendruscolo, Michele, Dobson, Christopher M., Schenk, Dale, Christodoulou, John, Toth, Gergely

Journal:

Year:

2009

Language:

english

File:

PDF, 3.07 MB

english, 2009

12

Local Cooperativity in an Amyloidogenic State of Human Lysozyme Observed at Atomic Resolution

Dhulesia, Anne, Cremades, Nunilo, Kumita, Janet R., Hsu, Shang-Te Danny, Mossuto, Maria F., Dumoulin, Mireille, Nietlispach, Daniel, Akke, Mikael, Salvatella, Xavier, Dobson, Christopher M.

Journal:

Journal of the American Chemical Society

Year:

2010

Language:

english

File:

PDF, 3.40 MB

english, 2010

13

Discovery of Specific Flavodoxin Inhibitors as Potential Therapeutic Agents against Helicobacter pylori Infection

Cremades, Nunilo, Velázquez-Campoy, Adrián, Martínez-Júlvez, Marta, Neira, José L., Pérez-Dorado, Inmaculada, Hermoso, Juan, Jiménez, Pilar, Lanas, Angel, Hoffman, Paul S., Sancho, Javier

Journal:

ACS Chemical Biology

Year:

2009

Language:

english

File:

PDF, 1.75 MB

english, 2009

14

The Flavodoxin from Helicobacter pylori : Structural Determinants of Thermostability and FMN Cofactor Binding †

Cremades, Nunilo, Velazquez-Campoy, Adrián, Freire, Ernesto, Sancho, Javier

Journal:

Year:

2008

Language:

english

File:

PDF, 519 KB

english, 2008

15

Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of alpha-synuclein oligomers

Horrocks, Mathew Harry, Tosatto, Laura, Dear, Alexander J, Garcia, Gonzalo Andres, Iljina, Marija, Cremades, Nunilo, Dalla Serra, Mauro, Knowles, Tuomas P.J., Dobson, Christopher M., Klenerman, David

Journal:

Analytical Chemistry

Year:

2015

Language:

english

File:

PDF, 6.66 MB

english, 2015

16

Cell surface localised Hsp70 is a cancer specific regulator of clathrin-independent endocytosis

Nimmervoll, Benedikt, Chtcheglova, Lilia A., Juhasz, Kata, Cremades, Nunilo, Aprile, Francesco A., Sonnleitner, Alois, Hinterdorfer, Peter, Vigh, Laszlo, Preiner, Johannes, Balogi, Zsolt

Journal:

Year:

2015

Language:

english

File:

PDF, 1.99 MB

english, 2015

17

Alpha-synuclein oligomers interact with metal ions to induce oxidative stress and neuronal death in Parkinson’s disease

Deas, Emma, Cremades, Nunilo, Angelova, Plamena R., Ludtmann, Marthe, Yao, Zhi, Chen, Serene, Horrocks, Mathew, Banushi, Blerida, Little, Daniel, Devine, Michael, Gissen, Paul, Klenerman, David, Dobso

Journal:

Antioxidants & Redox Signaling

Year:

2015

Language:

english

File:

PDF, 1.62 MB

english, 2015

18

Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading

Iljina, Marija, Garcia, Gonzalo A., Horrocks, Mathew H., Tosatto, Laura, Choi, Minee L., Ganzinger, Kristina A., Abramov, Andrey Y., Gandhi, Sonia, Wood, Nicholas W., Cremades, Nunilo, Dobson, Christo

Journal:

Proceedings of the National Academy of Sciences

Year:

2016

Language:

english

File:

PDF, 1.55 MB

english, 2016

19

Amyloid-β and α-Synuclein Decrease the Level of Metal-Catalyzed Reactive Oxygen Species by Radical Scavenging and Redox Silencing

Pedersen, Jeppe T., Chen, Serene W., Borg, Christian B., Ness, Samuel, Bahl, Justyna M., Heegard, Niels H. H., Dobson, Christopher M., Hemmingsen, Lars, Cremades, Nunilo, Teilum, Kaare

Journal:

Journal of the American Chemical Society

Year:

2016

Language:

english

File:

PDF, 1.51 MB

english, 2016

20

Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson’s disease genetically related mutants

Tosatto, Laura, Horrocks, Mathew H., Dear, Alexander J., Knowles, Tuomas P. J., Dalla Serra, Mauro, Cremades, Nunilo, Dobson, Christopher M., Klenerman, David

Journal:

Scientific Reports

Year:

2015

Language:

english

File:

PDF, 1.45 MB

english, 2015

21

The contribution of biophysical and structural studies of protein self-assembly to the design of therapeutic strategies for amyloid diseases

Cremades, Nunilo, Dobson, Christopher M.

Journal:

Neurobiology of Disease

Year:

2017

Language:

english

File:

PDF, 1.47 MB

english, 2017

22

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers

Fusco, Giuliana, Chen, Serene W., Williamson, Philip T. F., Cascella, Roberta, Perni, Michele, Jarvis, James A., Cecchi, Cristina, Vendruscolo, Michele, Chiti, Fabrizio, Cremades, Nunilo, Ying, Liming

Journal:

Year:

2017

Language:

english

File:

PDF, 909 KB

english, 2017

23

Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson’s Disease

Tóth, Gergely, Gardai, Shyra J., Zago, Wagner, Bertoncini, Carlos W., Cremades, Nunilo, Roy, Susan L., Tambe, Mitali A., Rochet, Jean-Christophe, Galvagnion, Celine, Skibinski, Gaia, Finkbeiner, Steve

Journal:

Year:

2014

Language:

english

File:

PDF, 692 KB

english, 2014

24

Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson’s Disease in Rodents

Polinski, Nicole K., Volpicelli-Daley, Laura A., Sortwell, Caryl E., Luk, Kelvin C., Cremades, Nunilo, Gottler, Lindsey M., Froula, Jessica, Duffy, Megan F., Lee, Virginia M.Y., Martinez, Terina N., D

Journal:

Journal of Parkinson s Disease

Year:

2018

Language:

english

File:

PDF, 1.04 MB

english, 2018

25

The extent of protein hydration dictates the preference for heterogeneous or homogeneous nucleation generating either parallel or antiparallel Î²-sheet Î±-synuclein aggregates

Camino, JosÃ© D., Gracia, Pablo, Chen, Serene W., Sot, JesÃºs, de la Arada, Igor, SebastiÃ¡n, VÃctor, Arrondo, JosÃ© L. R., GoÃ±i, FÃ©lix M., Dobson, Christopher M., Cremades, Nunilo

Journal:

Chemical Science

Year:

2020

File:

PDF, 1.08 MB

2020

26

Multiplicity of Î±-Synuclein Aggregated Species and Their Possible Roles in Disease

Gracia, Pablo, Camino, JosÃ© D., Volpicelli-Daley, Laura, Cremades, Nunilo

Journal:

International Journal of Molecular Sciences

Year:

2020

File:

PDF, 2.64 MB

2020

27

The role of water in the primary nucleation of protein amyloid aggregation

Camino, JosÃ© D., Gracia, Pablo, Cremades, Nunilo

Journal:

Biophysical Chemistry

Year:

2020

File:

PDF, 313 KB

2020